Five warriors challenge Ogami to duels. Each holds a part of information needed to complete the assassination of a mad clan leader.
Ogami is hired to kill a tattooed female assassin. Gunbei Yagyu, an enemy samurai, happens upon Ogami's son, and sees his chance for revenge.
In the sixth and final film of the Lone Wolf and Cub series, the final conflict between Ogami Itto and the Yagyu clan is carried out.