A depressed uncle is asked to take care of his teenage nephew after the boy's father dies.
Eddie Brock attempts to reignite his career by interviewing serial killer Cletus Kasady, who becomes the host of the symbiote Carnage and escapes prison after a failed execution.
When Eddie Brock acquires the powers of a symbiote, he will have to release his alter-ego "Venom" to save his life.
The story of a young boy in the Midwest is told simultaneously with a tale about a young girl in New York from fifty years ago as they both seek the same mysterious connection.