Best Female Lead movies of 2000s

Actors : Katie Holmes, Anna Paquin, Josh Duhamel, Malin Akerman,
Directors : Galt Niederhoffer,

Seven close friends reunite for the wedding of two of their friends. Problems arise because the bride and the maid of honor have had a long rivalry over the groom.

Actors : Brett Jacobsen, Claire Sloma, Marlon Morton, Amanda Bauer,
Directors : David Robert Mitchell,

Four young people navigate the suburban wonderland of metro-Detroit looking for love and adventure on the last weekend of summer.

Actors : Anastasia Hille, Valentin Ganev, Karel Roden, Valentin Goshev,
Directors : Nacho Cerdà,

An adopted woman returns to her home country and the family home that she never knew and must face the mystery that lies there.

Actors : Columbus Short, Jay Hernandez, Steve Harris, Jennifer Carpenter,
Directors : John Erick Dowdle,

A television reporter and her cameraman are trapped inside a building quarantined by the CDC, after the outbreak of a mysterious virus which turns humans into bloodthirsty killers.

Actors : Marc Barbé, Marie Féret, David Moreau, Delphine Chuillot,
Directors : René Féret,

A reimagined account of the early life of Maria Anna 'Nannerl' Mozart, five years older than Wolfgang, and a musical prodigy in her own right.

Actors : Anna Paquin, Giancarlo Giannini, Lena Olin, Iain Glen,
Directors : Jaume Balagueró,

A teenage girl moves into a remote countryside house with her family, only to discover that their gloomy new home has a horrifying past that threatens to destroy the family.

Actors : Justin Timberlake, Samuel L. Jackson, Christina Ricci, S. Epatha Merkerson,
Directors : Craig Brewer,

A God-fearing bluesman takes to a wild young woman who, as a victim of childhood sexual abuse, looks everywhere for love, never quite finding it.

Actors : Michael Ealy, Courteney Cox, Dori Mizrahi, James Le Gros,
Directors : Greg Harrison,

Sophie Jacobs is going through the most difficult time of her life. Now, she just has to find out if it's real.

Actors : Kathy Bates, Alfre Woodard, Sanaa Lathan, Rockmond Dunbar,
Directors : Tyler Perry,

Two families from different walks of life learn to work together.

Actors : Kendra C. Johnson, Jimmy Jean-Louis, Godfrey, Mo'Nique,
Directors : Nnegest Likké,

Two plus-sized ladies meet the men of their dreams in the most unexpected of ways.

Actors : Sibel Kekilli, Settar Tanriögen, Derya Alabora, Nizam Schiller,
Directors : Feo Aladag,

Umay is a young woman of Turkish descent, fighting for an independent and self-determined life in Germany against the resistance of her family. Her struggle initiates a dynamic, which results in a life-threatening situation.

Actors : Rip Torn, Darren E. Burrows, Dina Korzun, Andrew Lawrence Henderson,
Directors : Ira Sachs,

A Russian woman living in Memphis with a much older rock-'n'-roll legend experiences a personal awakening when her husband's estranged son comes to visit.

Actors : Fumiko Orikasa, Shôzô Îzuka, Miyoko Shôji, Mami Koyama,
Directors : Satoshi Kon,

A TV interviewer and his cameraman meet a former actress and travel through her memories and career.

Actors : Joy Bryant, Gena Rowlands, Peter Sarsgaard, Kate Hudson,
Directors : Iain Softley,

A hospice nurse working at a spooky New Orleans plantation home finds herself entangled in a mystery involving the house's dark past.

Actors : Rosemarie Bergmans, Julienne De Bruyn, Dora van der Groen, Ann Petersen,
Directors : Lieven Debrauwer,

Pauline is a 'little girl of 66 years old'. She is intellectually disabled and been cared after by her sister Martha. When Martha dies, her two younger sisters, Paulette and Cecile have to ...

Actors : Liam Aiken, Garrett Strommen, Vincent Perez, Kim Basinger,
Directors : Hugh Hudson,

Kuki, a divorced Italian socialite, changes her life after a serious car crash. She accepts a marriage proposal from Paolo Gallmann, a man she doesn't know well, and she moves to Kenya with...

Actors : Rachel Weisz, Susan Sarandon, Mark Wahlberg, Saoirse Ronan,
Directors : Peter Jackson,

Centers on a young girl who has been murdered and watches over her family - and her killer - from purgatory. She must weigh her desire for vengeance against her desire for her family to heal.

Actors : Manuela Velasco, Ferran Terraza, Jorge-Yamam Serrano, Pablo Rosso,

A television reporter and cameraman follow emergency workers into a dark apartment building and are quickly locked inside with something terrifying.

Actors : Bai Ling, Byung-hun Lee, Kyoko Hasegawa, Pauline Lau,

An Asian cross-cultural trilogy of horror films from accomplished indie directors.

Actors : Richard E. Grant, Reese Witherspoon, James McAvoy, Christina Ricci,
Directors : Mark Palansky,

A modern romantic tale about a young aristocratic heiress born under a curse that can only be broken when she finds true love with "one who will accept her as one of their own."