Best Female Lead movies of 2000s

Actors : Halle Berry, Stellan Skarsgård, Phylicia Rashad, Chandra Wilson,
Directors : Geoffrey Sax,

A drama centered on a go-go dancer with multiple personality disorder who struggles to remain her true self and begins working with a psychotherapist to uncover the mystery of the inner ghosts that haunt her.

Actors : Elias Koteas, Virginia Madsen, Martin Donovan, Kyle Gallner,
Directors : Peter Cornwell,

After a family is forced to relocate for their son's health, they begin experiencing supernatural behavior in their new home, and uncover a sinister history.

Actors : Bruce McFee, Jeff Seymour, David Calderisi, Kate Greenhouse,
Directors : Paul Fox,

The thirty and something years old psychiatrist Dr. Samantha Goodman has an incurable brain tumor that has just started to grow. Felling totally stressed, she decides to spend the weekend ...

Actors : Eliza Dushku, Wes Bentley, Melissa Sagemiller, Casey Affleck,
Directors : Stephen Carpenter,

A co-ed is caught between the world of the living and the dead.

Actors : Heino Ferch, Barbara Sukowa, Hannah Herzsprung, Lena Stolze,
Directors : Margarethe von Trotta,

The life story of the multi-talented German nun Hildegard von Bingen. The film portrays an original woman - best known as a composer and religious visionary - whose grand claims often run ...

Actors : Antonio Catania, Giuseppe Battiston, Bruno Ganz, Licia Maglietta,
Directors : Silvio Soldini,

After being forgotten in a highway café during a bus trip, a housewife decides to start a new life by herself in Venice.

Actors : Liam Hemsworth, Greg Kinnear, Miley Cyrus, Bobby Coleman,
Directors : Julie Anne Robinson,

A rebellious girl is sent to a Southern beach town for the summer to stay with her father. Through their mutual love of music, the estranged duo learn to reconnect.

Actors : Pablo Derqui, Belén Rueda, Lluís Homar, Francesc Orella,
Directors : Guillem Morales,

The story of a woman who is slowly losing her sight whilst trying to investigate the mysterious death of her twin sister.

Actors : Natasha Henstridge, Ice Cube, Jason Statham, Pam Grier,
Directors : John Carpenter,

In 2176, a Martian police unit is sent to pick up a highly dangerous criminal at a remote mining post. Upon arrival, the cops find that the post has become a charnel house.

Actors : Ben Shenkman, Michael Cerveris, Timothy Hutton, Julianne Nicholson,
Directors : John Krasinski,

A graduate student (Nicholson) copes with a recent breakup by conducting interviews with various men.

Actors : Liam Neeson, Christina Ricci, Justin Long, Chandler Canterbury,
Directors : Agnieszka Wojtowicz-Vosloo,

After a car accident, a young woman who is caught between life and death, meets a funeral director who appears to have the gift of transitioning the dead into the afterlife.

Actors : Margherita Buy, Serra Yilmaz, Gabriel Garko, Stefano Accorsi,
Directors : Ferzan Ozpetek,

AIDS doctor Antonia's husband is killed by a car. She gets depressed until she learns he had been cheating on her with a man. Following her newly born curiosity for life, she goes to see ...

Actors : Karina Testa, Patrick Ligardes, Samuel Le Bihan, Aurélien Wiik,
Directors : Xavier Gens,

A gang of young thieves flee Paris during the violent aftermath of a political election, only to hole up at an Inn run by neo-Nazis.

Actors : James Franco, Neve Campbell, Malcolm McDowell, Barbara E. Robertson,
Directors : Robert Altman,

Ensemble drama centered around a group of ballet dancers, with a focus on one young dancer (Campbell) who's poised to become a principal performer.

Actors : Hamed Behdad, Negar Shaghaghi, Ashkan Koshanejad, Babak Mirzakhani,
Directors : Bahman Ghobadi,

Iranian musicians Negar and Ashkan look for band members to play at a London concert - and the visas that allow them to leave Tehran to do so.

Actors : Dana Snyder, Dave Willis, Carey Means, Andy Merrill,

An action epic that explores the origins of Master Shake, Frylock, and Meatwad, better known as the Aqua Teen Hunger Force, who somehow become pitted in a battle over an immortal piece of exercise equipment.

Actors : Jesper Christensen, Maria Heiskanen, Callin Öhrvall, Mikael Persbrandt,
Directors : Jan Troell,

In a time of social change and unrest, war and poverty, a young working class woman, Maria, wins a camera in a lottery. The decision to keep it alters her whole life.

Actors : Zach Gilford, Emmy Rossum, Ashley Springer, Cady Huffman,
Directors : Adam Salky,

A drama centered around three high school seniors - an aspiring actress, her misfit best friend, and a loner - who become engaged in an intimate and complicated relationship.

Actors : Zoé Auclair, Lea Bridarolli, Bérangère Haubruge, Marion Cotillard,
Directors : Lucile Hadzihalilovic,

A look inside an offbeat boarding school for young girls.

Actors : Queen Latifah, Djimon Hounsou, Andie MacDowell, Alicia Silverstone,
Directors : Bille Woodruff,

A determined hairstylist (Queen Latifah) competes with her former boss (Kevin Bacon) after opening her own business in Atlanta.