Best Female Lead movies of 2000s

Actors : Biana Tamimi, Richard Romanus, Patrick Elyas, Gérard Rudolf,
Directors : Simon Wincer,

A young girl befriends a wild black stallion.

Actors : Asia Argento, Cristian Solimeno, Adam James, Moran Atias,
Directors : Dario Argento,

Part three of the "Three Mothers" trilogy which takes place in Rome and has to do with Mater Lachrymarum (The Third Mother).

Actors : Asia Argento, Jean Shepard, Herbert Fritsch, Gianluca Arcopinto,
Directors : Asia Argento,

A young Italian actress embarks on a self-destructive spree of sex, drugs and other excess while doing some soul searching to find the path for redemption.

Actors : Justin Long, Agnes Bruckner, John Corbett, Kelli Garner,
Directors : Jason Matzner,

A young woman who lives in a desert trailer park must choose between caring for her hapless father and sick friend or fulfilling her own destiny.

Actors : Anna Tsuchiya, Kyoko Fukada, Sadao Abe, Hiroyuki Miyasako,
Directors : Tetsuya Nakashima,

Momoko, a strange and seemingly emotionless girl obsessed with 18th century France, befriends a Yanki biker and the two experience the ups and downs of their unusual lives in a rural Japanese town.

Actors : Mélusine Mayance, Arthur Peyret, Alexandra Lamy, Sergi López,
Directors : François Ozon,

When Katie, an ordinary woman, meets Paco, an ordinary man, something magical happens: a love story. From this union an extraordinary child is born: Ricky.

Actors : Jaymie Dornan, Matt Ross, Rip Torn, Famke Janssen,
Directors : Chris Eigeman,

A pool shark takes the ultimate gamble when she kidnaps her own son and flees her ex-husband.

Actors : Rebecca De Mornay, Briana Evigan, Shawn Ashmore, Jaime King,
Directors : Darren Lynn Bousman,

The sadistic members of a villainous family return to their childhood home to terrorize the new home owners and their guests.

Actors : Bianca Hunter, Kevin Corrigan, Vincent D'Onofrio, Paz de la Huerta,
Directors : Ethan Hawke,

This movie tells five stories set in a single day at the famed Chelsea Hotel in New York City, involving an ensemble cast of some 30-35 characters.

Actors : Johan Heldenbergh, Barbara Sarafian, Jurgen Delnaet, Anemone Valcke,
Directors : Christophe Van Rompaey,

Matty, a 41-year old mother of three with a husband in his midlife-crisis, meets 29-year old Johnny, a truck driver, who takes an interest in her.

Actors : Carice van Houten, Theo Maassen, Sarah Bannier, Pierre Bokma,
Directors : Vincent Bal,

A cat who turns into a young woman helps a journalist protect their town from a factory boss with an evil plan.

Actors : Mare Winningham, Taryn Manning, Arliss Howard, Vincent Kartheiser,
Directors : Mark Milgard,

In a small town of rolling fields and endless skies, isolated 16 year old Mason lives in a world where families exist in fragmented silence and love seems to have gone missing. Then Mason ...

Actors : Shanti Roney, Blanca Engström, Calle Lindqvist, Annika Hallin,
Directors : Fredrik Edfeldt,

Story of a nine-and-a-half year old girl left alone in Sweden while her family is in Africa during the summer of 1981.

Actors : Rondel Reynoldson, Eva Bourne, Michael Rogers, Scott Hylands,
Directors : Panos Cosmatos,

Despite being under heavy sedation, a young woman tries to make her way out of the Arboria Institute, a secluded, quasifuturistic commune.

Actors : Anne Heche, Christina Ricci, Jonathan Rhys Meyers, Jessica Lange,
Directors : Erik Skjoldbjærg,

A young woman struggles with depression during her first year at Harvard.

Actors : Jenjira Pongpas, Nantarat Sawaddikul, Jaruchai Iamaram, Sophon Pukanok,
Directors : Apichatpong Weerasethakul,

Story about director Apichatpong Weerasethakul's parents who were both doctors, and director's memories about growing up in the hospital environment.

Actors : Olivier Gourmet, Madeleine Budd, Isabelle Huppert, Adélaïde Leroux,
Directors : Ursula Meier,

Life for an isolated rural family is upended when a major highway next to their property, constructed 10 years before but apparently abandoned, is finally opened.

Actors : Kate Dollenmayer, Mark Herlehy, Christian Rudder, Jennifer L. Schaper,
Directors : Andrew Bujalski,

Marnie just graduated from college, drinks likes she's still in school, and is looking for a temporary job but a permanent boyfriend. She loves a guy who doesn't love her (?), ping-pongs ...

Actors : Marie-Josée Croze, Jean-Nicolas Verreault, Stephanie Morgenstern, Pierre Lebeau,
Directors : Denis Villeneuve,

After plunging her car into a river, a woman encounters a man who helps her come to terms with her life.

Actors : Nicole Garcia, Guillaume Depardieu, Gil Alma, Aure Atika,

Several scary black-and-white animated segments in different styles appeal to our fear(s) of the dark.